윤혜원

  #분자영상

학력

1984.03 ~ 1988.02 서울대학교 자연과학대학 이학사
1988.03 ~ 1990.02 서울대학교 자연과학대학 이학석사
1996.01 ~ 2000.12 Texas Tech Univ. Biological Sciences. PhD 이학박사

경력

1996 ~ 2000 / Texas Tech Univ. Teaching / Research Assistant
2000 ~ 2002 / Texas Tech Health Sciences Center, Postdoctoral Fellow
2002 ~ 2005 / SouthWest Cancer Center, Research Associate/Instructor
2005 ~ 2006 / Univ. Kansas Medical Center, Urology Research Lab Director/Instructor
2007 ~ 2008 / 인하대학교 의학연구원 미생물학교실 연구교수
2008 ~ 2011 / 서울대학교 의학연구원 방사선의학연구소 연구 부교수
2011 ~ 현재 / 서울대학교 암병원 종양영상센터 임상 부교수

논문

Secreted protein acidic and rich in cysteine mediates active targeting of human serum albumin in U87MG xenograft mouse models.

Adenine Nucleotide Translocase 2 as an Enzyme Related to [18F] FDG Accumulation in Various Cancers.

18F-FEDAC as a Targeting Agent for Activated Macrophages in DBA/1 Mice with Collagen-Induced Arthritis: Comparison with 18F-FDG.

In vivo imaging of activated macrophages by 18F-FEDAC, a TSPO targeting PET ligand, in the use of biologic disease-modifying anti-rheumatic drugs (bDMARDs).

Neuroendocrine differentiation of prostate cancer leads to PSMA suppression.

Toward redesigning the PEG surface of nanocarriers for tumor targeting: impact of inner functionalities on size, charge, multivalent binding, and biodistribution.

Thyroid-Related Protein Expression in the Human Thymus.

The Potential Roles of Radionanomedicine and Radioexosomics in Prostate Cancer Research and Treatment.

Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells.

Simultaneous Detection of EGFR and VEGF in Colorectal Cancer using Fluorescence-Raman Endoscopy.

Preclinical evaluation of isostructural Tc-99m- and Re-188-folate-Gly-Gly-Cys-Glu for folate receptor-positive tumor targeting.

A new fluorescence/PET probe for targeting intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated IgM.

Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas.

Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α

Modified mRNA as an alternative to plasmid DNA (pDNA) for transcript replacement and vaccination therapy

A novel hNIS/tdTomato fusion reporter for visualizing the relationship between the cellular localization of sodium iodide symporter and its iodine uptake function under heat shock treatment

STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody

Glycosylation of Sodium/Iodide Symporter (NIS) Regulates Its Membrane Translocation and Radioiodine Uptake

EVpedia: a community web portal for extracellular vesicles research

Fluorescence-Raman dual modal endoscopic system for multiplexed molecular diagnostics

Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines

Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells

Codon-optimized human sodium iodide symporter (opt-hNIS) as a sensitive reporter and efficient therapeutic gene

Targeting BRG1 chromatin remodeler via its bromodomain for enhanced tumor cell radiosensitivity in vitro and in vivo

Subdominant H60 antigen-specific CD8 T-cell response precedes dominant H4 antigen-specific response during the initial phase of allogenic skin graft rejection

Relationship between apoptosis imaging and radioiodine therapy in tumor cells with different sodium iodide symporter gene expression

In vivo bioluminescence imaging of transplanted mesenchymal stem cells as a potential source for pancreatic regeneration

In vivo brain delivery of v-myc overproduced human neural stem cells via the intranasal pathway: tumor characteristics in the lung of a nude mouse

In vivo bioluminescence imaging for prolonged survival of transplanted human neural stem cells using 3D biocompatible scaffold in corticectomized rat model

Lesionalized therapy beyond personalized therapy in cancer management

Cytoplasmic parafibromin/hCdc73 targets and destabilizes p53 mRNA to control p53-mediated apoptosis

In vivo bioluminescence imaging for viable human neural stem cells incorporated within in situ gelatin hydrogels

In vivo bioluminescence reporter gene imaging for the activation of neuronal differentiation induced by the neuronal activator neurogenin 1 (Ngn1) in neuronal precursor cells

Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK)

In vivo visualization and monitoring of viable neural stem cells using noninvasive bioluminescence imaging in the 6-hydroxydopamine-induced mouse model of Parkinson disease

Primo vessel as a novel cancer cell migration path from testis with nanoparticle-labeled and GFP expressing cancer cells

Reporter gene imaging

Ultra-sensitive, biocompatible, quantum dots-embedded silica nanoparticles for bio-imaging,

Complementary treatment of siTERT for improving the anti-tumor effect of TERT-specific I-131 therapy

Development and in vivo imaging of a PET/MRI nanoprobe with enhanced NIR fluorescence by dye encapsulation

Casein kinase 2 inhibition attenuates androgen receptor function and cell proliferation in prostate cancer cells.

In vivo imaging of difference in early proliferation of donor cells in graft-versus-host disease hosts with different pre-conditioning doses

Nanoparticles modified by encapsulation of ligands with a long alkyl chain to affect multispecific and multimodal imaging

In vivo Noninvasive Small Animal Molecular Imaging

GFP-tagged E. coli shows bacterial distribution in mouse organs: pathogen tracking using fluorescence signal

In vivo non invasive molecular imaging for immune cell tracking in small animals

The role of regulatory T cells during the attenuation of graft-versus-leukemia activity following donor leukocyte infusion in mice

The influence of pre-transplant conditioning on graft-versus-leukemia effect in mice

Tumor Targeting and Imaging Using Cyclic RGD-PEGylated Gold Nanoparticle Probes with Directly Conjugated Iodine-125.

The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH

A brain-targeted non-toxic RVG-SSPEI nanocarrier for efficient delivery of neurogenic microRNA.

G-protein alpha-s and -12 subunits are involved in androgen-stimulated PI3K activation and adrogen receptor transactivation in prostate cancer cells

Effects of Pre-conditioning dose on the Immune Kinetics and Cytokine Production in the Leukocytes Infiltrating GVHD Tissue after MHC-mached Transplantation

Molecular Imaging Using PET/MRI particle

A new PET probe, (18)F-tetrafluoroborate, for the sodium/iodide symporter: possible impacts on nuclear medicine.

Sodium Iodide Symporter and the Radioiodine Treatment of Thyroid Carcinoma.

Human sodium/iodide symporter-mediated radioiodine gene therapy enhances the killing activities of CTLs in a mouse tumor model

Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of beta-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein.

Cyclodextrin-Covered Gold Nanoparticles for Targeting delivery of Anti-Cancer Drug.

1-Methylxanthine Enhances the Radiosensitivity of Tumor cells by Abrogating Radiation-Induced G2 Checkpoint Activation.

Nanomedicine: Drug Delivery Systems and Nanoparicle Targeting

Block Copolymer Micelles Conjugated with anti-EGFR for Targeted Delivery of Anticancer Drug

Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers

ICAM-1 expression in vaginal cells as a potential biomarker for inflammatory response.

Conditional Akt activation promotes androgen-independent progression of prostate cancer.

FAM20: an evolutionary conserved family of secreted proteins expressed in hematopoietic cells.

Mapping gene expression patterns during myeloid differentiation using the EML hematopoietic progenitor cell line.

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